THE K-CA ANTAGONISM IN REGARD TO ABSORPTION FROM THE INTESTINE

Abstract
Slight changes in the concn. of KC1 and CaCl2 in a soln. perfusing the blood vessels of the gut of a frog (Rana esculenta) change the permeability of the gut to glucose. The absence of both K and Ca from the perfusing fluid increases reversibly the permeability to glucose. The absorption of glucose is increased by K and decreased by Ca. Concns. of 0.01 to 0.02% of CaCl2 seem to have a cumulative irreversible effect on the gut frequently leading to a gradual decrease of glucose absorption. The pH and the osmotic pressure of the perfusing fluid were kept constant. A practically constant perfusion rate was maintained throughout the entire expt.

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