A Study of the Mechanism of the Increase in Cardiac Output Induced by Isopropylarterenol Hydrochloride (Isuprel).

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Abstract
The effect of Isuprel on mean arterial blood pressure, cardiac output and total peripheral resistance has been investigated in the anesthetized dog in which the effect of the drug on heart rate is allowed to occur as well as in the anesthetized dog in which electrically induced atrial or ventricular tachycardia is initiated before and maintained throughout the period of action of the drug in order to prevent the increase in heart rate normally induced by the drug. Under these experimental circumstances the effect of the drug on cardiac output and total peripheral resistance is essentially the same, whether the effect of the drug on heart rate is permitted or prevented.