INTERACTION OF CHOLINE WITH NICOTINIC AND MUSCARINIC CHOLINERGIC RECEPTORS IN THE RAT BRAIN IN VITRO
- 1 December 1984
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 11 (6) , 649-654
- https://doi.org/10.1111/j.1440-1681.1984.tb00878.x
Abstract
The ability of choline to interact with nicotinic receptors was investigated by measuring its ability to inhibit the specific binding of [3H]-nicotine in rat brain. Choline, with an IC50 of 241 mumol/l, was three times more potent than its analogue deanol and almost 1000-fold less potent than acetylcholine. Choline also inhibited the binding of the antagonist [3H]-quinuclidinyl benzilate (IC50 = 2.5 mmol/l) and of the agonist [3H]-oxotremorine-M (IC50 = 165 mumol/l) to muscarinic cholinergic receptors. These results indicate that choline is able to interact directly, in vitro with brain cholinergic receptors of both the nicotinic and muscarinic type.Keywords
This publication has 22 references indexed in Scilit:
- Nicotinic Cholinergic Receptor Binding Sites in the Brain: Regulation in VivoScience, 1983
- The effects of nicotine on brain neurotransmitter systemsPharmacology & Therapeutics, 1982
- The Cholinergic Hypothesis of Geriatric Memory DysfunctionScience, 1982
- Cholinergic System in Behavior: The Search for Mechanisms of ActionAnnual Review of Pharmacology and Toxicology, 1982
- Choline Stimulates Nicotinic Receptors on Adrenal Medullary Chromaffin Cells to Induce Catecholamine SecretionScience, 1981
- Presynaptic ReceptorsAnnual Review of Pharmacology and Toxicology, 1981
- Stereospecific Nicotine Receptors on Rat Brain MembranesScience, 1980
- Muscarinic receptor binding in rat brain using the agonist, [3H]cis methyldioxolaneLife Sciences, 1980
- Increase in rat brain acetylcholine induced by choline or deanolLife Sciences, 1975
- Brain acetylcholine: Increase after systematic choline administrationLife Sciences, 1975