Immobilized live cell reactor dynamics following dilution rate shift to growth conditions: Cell synchrony effects

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Abstract
Nutrient deprivation was used to synchronize an immobilized live cell culture of Acetobacter suboxydans. The substrate supply was increased by a step change in the dilution rate to the reactor. Oscillations in cell, substrate, and product concentrations were observed. A population balance model was developed to explain the observed reactor dynamics. Simulation results based on the model were used to substantiate the premise that cell synchrony is the likely phenomenon responsible for the observed oscillations. The implications of cell synchrony in immobilized cell systems are discussed briefly.