The Binding of Diiodosalicylate and Flufenamate to the Plasma Antiactivator: Analysis of Chemical Fibrinolysis
- 1 January 1979
- journal article
- research article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 41 (02) , 357-364
- https://doi.org/10.1055/s-0038-1646785
Abstract
The fibrinolytic effect of diiodosalicylate was expressed as apparent units urokinase. The dissociation constant of the urokinase-inhibitor complex is increased 19 times in the presence of 10-2 M diiodosalicylate. The binding of diiodosalicylate to the antiactivator was estimated and the increase in free urokinase in the presence of diiodosalicylate was calculated. With 10-2 M diiodosalicylate present only 4% of the inhibitor remains free to bind urokinase. Therefore, the fibrinolytic action of diiodosalicylate can be explained on the basis of its binding to the inhibitor and the release of free urokinase.This publication has 4 references indexed in Scilit:
- Plasmatic and Platelet Anti-Plasmins and Anti-ActivatorsThrombosis and Haemostasis, 1967
- The fibrinolytic activity of N-arylanthranilatesBiochemical Pharmacology, 1966
- A Simple Test Tube Arrangement for Screening Fibrinolytic Activity of Synthetic Organic Compounds1Journal of Medicinal Chemistry, 1965
- Fibrinolysis induction in vitro by aromatic derivativesArchives of Biochemistry and Biophysics, 1962