Metabolism of endogenous plasma triglyceride in familial hypercholesterolaemia: studies of affected and unaffected siblings of two kindreds

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Abstract
Plasma endogenous triglyceride kinetics were investigated using [3H]glycerol in 5 unaffected and 8 affected (heterozygous) siblings of 2 kindreds with familial hypercholesterolemia. No consistent differences between affected and unaffected siblings regarding plasma triglyceride levels or apparent triglyceride production rates as determined over 10 h were seen, and the values observed were generally within the ranges seen in 12 normolipidemic controls. Abnormal plasma triglyceride metabolism is apparently not a feature of heterozygous familial hypercholesterolemia.