PREDICTIVE VALUE OF ANTI-DNA ANTIBODY AND SELECTED LABORATORY STUDIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 7  (6) , 843-849
Abstract
In a retrospective study of 71 patients with systemic lupus erythematosus (SLE), a large number of clinical and laboratory variables were studied to determine their predictive value of morbidity and mortality. Patients were followed for an average of 57 mo. Anti-DNA antibody, Hb and creatinine levels at initial evaluation correlated significantly (P < 0.05) for subsequent course of SLE, although each parameter was not a good predictor for final outcome. Anti-DNA correlated better with subsequent course in patients who were diagnosed within 12 mo. of the initial evaluation. By comparison, other measured parameters were not predictive at all. Anti-DNA, Hb, creatinine and C3 [complement component 3] levels at the time of most recent evaluation (date last seen) correlated strongly (P < 0.01 - P < 0.001) with concurrent clinical status.