Susceptibility of Cortisone-treated Mice to Infection with Mouse Hepatitis Virus.

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Abstract
Cortisone acetate reduced the susceptibility of normally resistant weanling Swiss mice to infection with the Gledhill strain (MHV 1) of mouse hepatitis virus. The effectiveness of cortisone was enhanced as the dosage of the steroid was increased. There was a decrease in this cortisone effect as the time interval between virus and cortisone administration was increased from 1 to 5 days. A small proportion of mice inoculated with cortisone alone died or developed ascites and/or pin-point liver lesions. Homogenates of such livers were not infective for normal mice.