Evidence for antral inhibition of pentagastrin from experiments using mucosal cooling.

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Abstract
The acid secretion of the fundic mucosa in Heidenhain pouches in response to pentagastrin became progressively less as the pouch mucosa was cooled. When a cooled Heidenhain pouch in an animal receiving pentagastrin was warmed, acid and pepsin secretion from the main stomach was depressed. Change from warm to cool produced no obvious effect. In animals receiving pentagastrin continuously, but not in those receiving histamine, lowering the temperature in an antral pouch or the amplification of local anesthetics to its mucosa, increased acid and pepsin secretion from the main stomach when the antral pouch was fully innervated. This effect could readily be abolished by ganglionic and .beta.-adrenergic blockade but not by bilateral vagal block in the neck, thus suggesting a sympathetically mediated inhibitory mechanism of pyloric origin. The effect of indirect vagal stimulation, using 2-deoxy-D-glucose on secretion from the main stomach, was augmented by pyloric antral local anesthesia and depressed by antral cooling.