The effects of isoprenaline and noradrenaline on pentagastrin‐stimulated gastric acid secretion and mucosal blood flow in the dog

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Abstract
1 . Isoprenaline (0·02 to 2·0 μg kg−1 min−1) inhibited gastric secretion in response to pentagastrin in both conscious and anaesthetized dogs and in response to feeding in conscious dogs. 2 . The inhibition was unaffected during cardiac β-adrenoceptor blockade by propranolol. 3 . The inhibition was not due to decreased mucosal blood flow. 4 . This effect of isoprenaline is different from its effect on histamine-induced gastric secretion. 5 . Noradrenaline (0·05–2·0 μg kg−1 min−1) also decreased gastric secretion but it was less effective than isoprenaline. 6 . The mechanism of action of noradrenaline is probably a decrease in mucosal blood flow.