Studies on the Adrenal

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Abstract
The adrenal cortical hormone was found to have no demonstrable replacement activity in experimental avitaminosis B or G. The apparent partial replaceability of vitamin C by adrenal cortical preparations reported by previous observers is due to the presence of ascorbic acid in such extracts. Crystalline vitamin C is more effective when administered intraperitoneally than by mouth. Ascorbic acid does not prolong the life of adrenalectomized animals. The other considerations which have led previous observers to assume the existence of an intimate relation between the adrenal cortex and vitamin deficiencies are explicable on the assumption that the hormone and vitamins are necessary for the proper functioning of a great number of organs and tissues.

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