Intense oxidative DNA damage promoted by l‐DOPA and its metabolites implications for neurodegenerative disease
- 19 October 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 353 (3) , 246-250
- https://doi.org/10.1016/0014-5793(94)01056-0
Abstract
Oxidative DNA damage can cause mutation and cell death. We show that l-DOPA, dopamine and 3-O-methyl-DOPA cause extensive oxidative DNA damage in the presence of H2O2 and traces of copper ions. 8-Hydroxyguanine is the major product. Iron ions were much less effective and manganese ions did not catalyse DNA damage. We propose that copper ion release, in the presence of l-DOPA and its metabolites, may be an important mechanism of neurotoxicity, e.g. in Parkinson's disease and amyotrophic lateral sclerosis.Keywords
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