The Disposition and Metabolism of I.C.I. 58,834 (Viloxazine) in Humans
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 5 (2) , 113-129
- https://doi.org/10.3109/00498257509056097
Abstract
1. 2-(2 - Ethoxyphenoxymethyl) - 2,3,5,6 -tetrahydro - 1,4 - oxazine (I.C. I. 58,834)* in three 14C-labelled forms, given orally to two male volunteers, was completely absorbed, extensively metabolized and rapidly eliminated via the kidney. 2. O-Dealkylation, the major metabolic pathway in the rat, was not significant in man. 3. The major component in blood at all times was I.C.I. 58,834, which had a blood half-life of 4 h. The level of 14C in blood at 31 h was near the limit of detection. 4. The observed activity of the drug appears to be due to the parent compound alone.Keywords
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