THE ANESTHETIC MODIFICATION OF THE ENDOCRINE AND METABOLIC RESPONSE TO SURGERY

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 67  (1) , 25-29
Abstract
The metabolic and endocrine response to surgery has been investigated in detail for many years. The current view is that the response is detrimental to the patient and that the prevention or reduction of the changes may be beneficial in aiding recovery from surgery; 3 main methods are available at present for modifying the response. First, the use of afferent neuronal blockage, by epidural or spinal analgesia, to inhibit the transmission of impulses from the site of trauma. Secondly, the i.v. administration of large doses of potent opiate analgesics to block hypothalamic-pituitary function. Thirdly, the hormonal status of the patient may be changed, either by the use of agents to inhibit the secretion or action of the catabolic hormones or by the infusion of anabolic hormones such as insulin.