Vascular Complications in Diabetes Mellitus

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Abstract
The mechanisms responsible for acceleration of atherosclerosis in diabetes mellitus and the pathophysiologic meaning of different forms of diabetic microangiopathy remain enigmatic despite considerable research aimed at elucidating the role of genetic, metabolic, and physiologic factors in the pathogenesis of vascular disease in both nondiabetics and diabetics. Particular emphasis has been given to determining whether diabetic vascular disease is modulated by metabolic, hormonal, and physiologic disturbances secondary to insulin deficiency, or by genetic factors closely linked to but independent of factors governing susceptibility to insulin insufficiency.Such studies make several points clear. First of all, insulin deficiency produced in laboratory . . .