Antineoplastic agents. 168. Isolation and structure of axinohydantoin

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Abstract
Western (Palau) and Eastern (State of Truk) Caroline Islands and Papua New Guinea sponges of the genera Axinella and Hymeniacidon were found to contain the cytostatic (PS ED50 2.5 and 2.0 (μg/mL) and antineoplastic (PS T/C 143 at 3.6 mg/kg and T/C 138 at 3.6 mg/kg) pyrrologuanidines 1a and 1b. The related hydantoin 2, designated axinohydantoin, was also isolated from an Axinella sp. and its structure was assigned by X-ray crystallographic techniques. Present experience with sponges in the Axinella and Hymeniacidon genera suggests that the previously known hymenialdisine (1b) and analogous imidazole derivatives may be widely distributed among these and related orange colored Porifera. Keywords: axinohydantoin, hymenialdisine, Axinella, Hymeniacidon, cystostatic.

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