Low responder MHC alleles for Tc recognition of influenza nucleoprotein
- 1 June 1986
- journal article
- research article
- Published by Springer Nature in Immunogenetics
- Vol. 23 (6) , 379-384
- https://doi.org/10.1007/bf00372670
Abstract
Since virus nucleoprotein is an important target antigen for antiinfluenza cytotoxic T cells (Tc), we examined the genetics of Tc responses to this single viral protein to find three nonresponder alleles (D d, D k, and K b) in three haplotypes and their recombinants so far tested. B10.A(5R) mice bearing nonresponder MHC class I antigen in the D and K regions show no anti-NP Tc responses, however they do show a strong A-virus cross-reactive anti-influenza cytotoxicity. The high frequency of nonresponsiveness to a single viral component, as compared with the entire virus, has implications for the development of simple vaccines.Keywords
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