THE USE OF THE SHAY RAT IN STUDYING ANTI-ULCER SUBSTANCES

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Abstract
Intestinal extracts ad-ministered to Shay rats gave the following order of activity in both the 16 hr. assay (inhibition of gastric ulcers) and the 5 hr. assay (inhibition of gastric secretion): urogastrone, urine extract (Wick), enterogastrone, and acid extract of intestines. None of these prepns. was active when given orally. A correlation was found between either the depression of gastric secretion or concn. of acid in the 5 hr. assay and the inhibition of ulceration in the 16 hr. assay. The extracts that were tested did not seem to have a specific effect on pepsin secretion. It would appear that in the Shay rat, inhibition of gastric lesions by these extracts can be accounted for solely on the basis of their ani-secretory proper-ties.

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