THE EFFECT OF INTERFERON TREATMENT OF TARGETS ON SUSCEPTIBILITY TO CYTO-TOXIC LYMPHOCYTE-T KILLING - AUGMENTATION OF ALLOGENEIC KILLING AND VIRUS-SPECIFIC KILLING RELATIVE TO VIRAL-ANTIGEN EXPRESSION

  • 1 January 1985
    • journal article
    • research article
    • Vol. 56  (3) , 451-457
Abstract
The effect of CTL lysis of treatment of CTL targets with IFNs has been investigated. Treatment of targets for alloreactive CTL with either IFN-.alpha..beta. or IFN-.gamma. markedly augmented cytotoxicity. Cold competition experiments implied that CTL recognized the same target structure on both untreated and IFN-treated cells. This augmented lysis is presumably caused by IFN increasing expression of target MHC antigens. In the case of SFV-specific lysis of SFV-infected fibroblasts. IFN-.alpha..beta. or IFN-.gamma. treatment somewhat reduced CTL lysis, but less so than Ab + C lysis which was abolished at moderate IFN concentrations; in the case of SFV-infected lymphoblastoid cells, CTL lysis remained the same or was slightly increased, whilst Ab + C lysis was reduced at moderate IFN concentrations and abolished at high IFN concentration; in the case of MSV/MLV-infected fibroblasts, CTL lysis was moderately increased whilst Ab + C lysis was decreased. IFN therefore increases virus-specific CTL cytotoxicity relative to viral antigen expression.

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