Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity
- 1 October 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 305 (5937) , 776-779
- https://doi.org/10.1038/305776a0
Abstract
Evidence is presented that cells transformed by adenovirus type 12 are oncogenic because they escape from T-cell immunity. This effect is brought about by reducing the expression of class I transplantation antigens and is a function of the protein translated from the 13S mRNA, transcribed from early region 1a. These findings establish a novel mechanism by which transformed cells can acquire an oncogenic phenotype.This publication has 27 references indexed in Scilit:
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