Raman Dye-Labeled Nanoparticle Probes for Proteins
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- 8 November 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (48) , 14676-14677
- https://doi.org/10.1021/ja0366235
Abstract
In this paper, we demonstrate how one can chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities and use these probes, coupled with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed screening of protein−small molecule interactions and protein−protein interactions in a protein microarray format.Keywords
This publication has 14 references indexed in Scilit:
- Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA DetectionScience, 2002
- Oligonucleotide Adsorption to Gold Nanoparticles: A Surface-Enhanced Raman Spectroscopy Study of Intrinsically Bent DNAThe Journal of Physical Chemistry B, 2001
- Quantum-dot-tagged microbeads for multiplexed optical coding of biomoleculesNature Biotechnology, 2001
- Protein microarrays: prospects and problemsChemistry & Biology, 2001
- Ag Nanocrystal Junctions as the Site for Surface-Enhanced Raman Scattering of Single Rhodamine 6G MoleculesThe Journal of Physical Chemistry B, 2000
- Ultrasensitive Chemical Analysis by Raman SpectroscopyChemical Reviews, 1999
- Semiconductor Nanocrystals as Fluorescent Biological LabelsScience, 1998
- One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticle ProbesJournal of the American Chemical Society, 1998
- Surface-enhanced Raman scatteringChemical Society Reviews, 1998
- Stepwise Construction of Conductive Au Colloid Multilayers from SolutionChemistry of Materials, 1997