Splanchnic Nerve Transection Abolishes the Age‐Dependent Increase of Neuropeptide Y‐Like Immunoreactivity in Rat Adrenal Gland
- 1 May 1986
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 46 (5) , 1658-1660
- https://doi.org/10.1111/j.1471-4159.1986.tb01792.x
Abstract
Using an antiserum directed against porcine neuropeptide Y (NPY), a high concentration of NPY immunoreactivity (NPY-IR) was detected in rat adrenal gland. The level of NPY-IR in the adrenal gland was found to increase considerably with age. Biochemical characterization by reverse-phase HPLC indicated that this increase was due to accumulations of NPY and another molecular form of NPY-like immunoreactive peptide. Chronic denervation of the splanchnic nerve abolished this age-dependent increase of NPY-IR in rat adrenal gland.Keywords
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