ALTERATIONS IN THE WHITE BLOOD CELL PICTURE IN NORMAL, HYPOPHYSECTOMIZED AND SPLENECTOMIZED GUINEA PIGS DURING MILD STRESS AND FOLLOWING EPINEPHRINE INJECTION

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Abstract
The procedures involved in sampling blood from the ear vein in the unanaesthetized guinea pig induce a mild stress reaction. Within 1 hr. after drawing a blood sample the number of mononuclear cells and eosinophils decreased approx. 30 percent and this fall is sustained through the 3d hr. The number of polynuclear leucocytes is unaltered during this interval. The decline in eosinophils is dependent upon the presence of the hypophysis. The initial decrease in eosinophils requires the presence of the spleen but the later disappearance occurs in the splenectomized animal. Epinephrine administered subcut. causes a lymph-openia 3 hrs. after injn. which is independent of the hypophysis, and a marked polynuclear leucocytosis which is independent of the spleen. The characteristic eosinopenia anticipated 3 hrs. after epinephrine admn. does not occur. This atypical response is discussed.