INDUCTION OF PUBERTY LONG-TERM TREATMENT WITH HIGH-DOSE LHRH
- 1 July 1979
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 11 (1) , 81-87
- https://doi.org/10.1111/j.1365-2265.1979.tb03049.x
Abstract
Gonadotropin releasing hormone 500 .mu.g was administered twice daily to 4 patients (2 male, 2 female) with hypogonadotropic hypogonadism due to LHRH [luteinizing hormone releasing hormone] deficiency, for a minimum of 1 yr. Despite initially encouraging biochemical responses and physical changes in all 4 patients, gonadotropin responsiveness waned, sex steroid levels were not maintained and pubertal development did not occur. This diminishing responsiveness appears to be a severe limitation on the use of LHRH as a therapeutic agent.This publication has 9 references indexed in Scilit:
- Hypersensitivity of the Human Gonadotrophs to the Repeated Administration of Small Doses of LH-RHHormone Research, 1978
- TREATMENT OF CRYPTORCHIDISM BY INTRANASAL SYNTHETIC LUTEINISING-HORMONE RELEASING HORMONEThe Lancet, 1977
- REDUCED‘GONADOTROPHS RESPONSE TO RELEASING HORMONE’AFTER CHRONIC ADMINISTRATION TO IMPOTENT MENClinical Endocrinology, 1977
- The Use of Luteinizing Hormone-Releasing Hormone in Pediatric PatientsHormone Research, 1977
- Effect of a New LH-RH Analogue (D-Ser(TBU)6-EA10-LH-RH) on Gonadotrophin and Gonadal Steroid Secretion in MenHormone Research, 1976
- Serum LH and FSH Responses to the Repetitive Administration of Gonadotropin-Releasing Hormone in Patients with Idiopathic Hypogonadotropic HypogonadismJournal of Clinical Endocrinology & Metabolism, 1975
- STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONEThe Lancet, 1975
- Gonadotrophin-releasing Hormone Therapy in Hypogonadal Males with Hypothalamic or Pituitary DysfunctionBMJ, 1974
- Isolated Pituitary Gonadotrophin Deficiency: Gonadotrophin Secretion after Synthetic Luteinizing Hormone and Follicle Stimulating Hormone-releasing HormoneBMJ, 1972