Trauma and Acetylsalicylic Acid-Induced Changes in Hemostasis during Liver Resection in the Rat

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Abstract
The effect of acetylsalicylic acid and bilateral femoral crush fractures on hemostasis after liver resection was studied in the rat. Serum salicylate levels were dose-dependent and similar in traumatized and non-traumatized animals. Bleeding time was significantly shortened and blood loss significantly decreased after bilateral femoral crush fractures. Both these values were significantly increased in salicylate pretreated animals compared to controls. Combination of bilateral femoral crush fractures and administration of 0.7 mg/100 g b.w. acetylsalicylic acid brought blood loss to normal values, while administration of 4.3 mg/l00 g b.w. acetylsalicylic acid after bilateral femoral crush fractures increased blood loss significantly. Normal APT times indicated that the intrinsic coagulation system was not affected. ADP- and collagen-induced platelet aggregation was diminished in all animals as compared to controls.