The effect of papaverine on local tissue P O 2 and microflow in cat brain cortex

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Abstract
The effect of intracarotid and intravenous administration of papaverine on local tissue P O 2 and microflow in the cat's brain surface was studied. Local tissue P O 2 was measured with a multiwire surface electrode polaroraphically, and microflow by local hydrogen clearance method. The intracarotid infusions were made for 1, 2 and 5 min with doses of 0.1, 0.2 and 0.5 mg/kg/min papaverine, and the intravenous ones for 5 min with doses of 0.2, 0.5 and 1 mg/kg/min. The continuous intracarotid infusions showed that papaverine in the doses used distinctly increased local tissues P O 2 and microcirculation of the brain surface. With the doses applied, systemic arterial pressure (SAP) changed little. It slightly decreased only during the 5 min infusions containing 0.5 mg/kg/min. The duration of the effect increased with increases in the duration of the infusion and of the dose. The maximum duration was observed with 5 min infusions and lasted for 10–15 min after drug administration was discontinued. During the i.v. infusions, tissue P O 2 and microflow rose less than with intracarotid ones. No redistribution of capillary flow was observed.