The antagonism of ipsapirone induced biobehavioral responses by +/? pindolol in high and low impulsives

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Abstract
The present study was conducted to investigate whether +/− pindolol antagonizes ipsapirone induced biobehavioral changes in a personality dependent way. Our previous work demonstrated that high impulsives show higher immune cell responses than low impulsive subjects upon treatment with ipsapirone. A total number of 80 healthy male volunteers received placebo (N=20) or 10 mg ipsapirone (N=20), 30 mg +/− pindolol (N=20), or a combination of 30 mg +/− pindolol and 10 mg ipsapirone (N=20). Each group consisted of 10 low and 10 high impulsive subjects. Since 5-HT related drugs induce thermoregulatory responses, the study took place in a climate chamber with a constant ambient temperature. Blood samples (for measurement of CD4+ cell counts) were drawn from an indwelling catheter invisibly for the subjects. The results clearly demonstrate that the ipsapirone induced decreases in body temperature and number of peripheral CD4+ cells are more pronounced in high impulsives. +/− Pindolol antagonizes the thermoregulatory and CD4+ cell responses. The results are discussed with respect to mechanisms of alteration in 5-HT function related to impulsivity.

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