CORONARY DILATORY ACTION OF ADENOSINE-ANALOGS - COMPARATIVE-STUDY

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 230  (1) , 140-149
Abstract
The coronary dilatory action of 23 adenosine analogues was investigated on a comparative basis after i.v. administration in anesthetized dogs. Substitution of adenosine in position 5'' with a COOH group and esterification led to a 50- to 100-fold increase in coronary efficacy (flow increase integrated over the time of action). Amidation of the carboxylic acid analogue further enhanced the coronary efficacy. The most effective analogue, adenosine-5''-ethyl-carboxamide, showed 20,000 times greater activity than adenosine. Additional substitution in positions 2'' and 3'' with NO2, O-methoxy-methyliden or O-methoxyethyliden resulted in a delayed onset and prolonged duration of action.