Novel germline RET mutation segregating with papillary thyroid carcinomas
- 12 October 2001
- journal article
- research article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 32 (4) , 390-391
- https://doi.org/10.1002/gcc.1205
Abstract
The RET proto‐oncogene is responsible for inherited medullary thyroid cancer syndromes. RET is also found mutated in sporadic medullary thyroid cancer (MTC) and rearranged in sporadic papillary thyroid carcinomas. Here, we describe a previously unreported germline RET mutation at codon 603 in exon 10 associated with both MTC and nonmedullary thyroid cancer (NMTC) in a kindred. RET may thus not be excluded as a potential candidate for predisposition to some forms of NMTC.Keywords
Funding Information
- Centre Hospitalier Universitaire de Montpellier
- Institut National de la Santé et de la Recherche Médicale
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