Adjuvant Requirements for Protective Immunization of Mice Using a Trypanosoma cruzi 90K Cell Surface Glycoprotein
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 74 (4) , 373-377
- https://doi.org/10.1159/000233576
Abstract
A wide range of adjuvants including alhydrogel, saponin, Corynebacterium parvum, DDAB, Pfizer CP-20,961, oil adjuvants and several MDP analogues have been compared for their adjuvant activity in protecting mice against lethal Trypanosoma cruzi infection following immunization with a T. cruzi 90K cell surface glycoprotein. Only saponin was found to be effective. Promotion did not correlate with the ability to promote a particular Ig isotype; however, saponin was unique in its ability to promote cell-mediated immunity against the 90K glycoprotein.Keywords
This publication has 13 references indexed in Scilit:
- The nature of immunity against Trypanosoma crtczi in mice recovered from acute infectionParasite Immunology, 1981
- Trypanosoma cruzi: Role of different antibody classes in protection against infection in the mouseExperimental Parasitology, 1981
- Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oilInfection and Immunity, 1981
- Trypanosoma cruzi: In vivo and in vitro correlation between T-cell activation and susceptibility in inbred strains of miceExperimental Parasitology, 1981
- VARIABLE EXPRESSION OF DELAYED-HYPERSENSITIVITY IN DIFFERENT MOUSE STRAINS USING DIMETHYL DIOCTADECYL AMMONIUM BROMIDE AS AN ADJUVANT1980
- COMPARATIVE SELECTIVITY OF ADJUVANTS FOR HUMORAL AND CELL-MEDIATED-IMMUNITY .1. EFFECT ON THE ANTIBODY-RESPONSE TO BOVINE SERUM-ALBUMIN AND SHEEP RED-BLOOD-CELLS OF FREUNDS INCOMPLETE AND COMPLETE ADJUVANTS, ALHYDROGEL, CORYNEBACTERIUM-PARVUM, BORDETELLA-PERTUSSIS, MURAMYL DIPEPTIDE AND SAPONIN1980
- Effect of selenium and dimethyl dioctadecyl ammonium bromide on the vaccine-induced immunity of Swiss-Webster mice against malaria (Plasmodium berghei)Infection and Immunity, 1980
- Enhancement of host resistance against Trypanosoma cruzi infection by the immunoregulatory agent muramyl dipeptideInfection and Immunity, 1979
- Corynebacterium parvumas an adjuvant forTrypanosoma cruziepimastigote vaccines: a comparison with saponin andBordetella pertussisParasitology, 1979
- Stearic acid, an Essential Growth Factor for Trypanosoma cruziJournal of General Microbiology, 1963