Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil
- 1 July 1981
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 33 (1) , 312-314
- https://doi.org/10.1128/iai.33.1.312-314.1981
Abstract
Circulating antibody titers can be increased when the antigen is administered in an aqueous medium with N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide). Results reported here show that cell-mediated immunity can be demonstrated when this synthetic adjuvant or an active analog is injected with an antigen (ovalbumin) in metabolizable squalane emulsion. Under these conditions a lipophilic derivative of muramyl dipeptide was shown to be even more active and to enhance long-lasting immune responses.This publication has 15 references indexed in Scilit:
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