AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis
Open Access
- 15 June 2007
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 13 (12) , 3682-3688
- https://doi.org/10.1158/1078-0432.ccr-06-2979
Abstract
Purpose: In the current study, we examined the in vivo effects of AZD1152, a novel and specific inhibitor of Aurora kinase activity (with selectivity for Aurora B).Keywords
This publication has 19 references indexed in Scilit:
- PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral ActivityClinical Cancer Research, 2006
- Cooperation between Mitotic Kinesins Controls the Late Stages of CytokinesisCurrent Biology, 2006
- Tetraploidy and tumor developmentCancer Cell, 2005
- Aurora kinases: shining lights on the therapeutic horizon?Oncogene, 2005
- Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinasePublished by Wiley ,2005
- Aurora-kinase inhibitors as anticancer agentsNature Reviews Cancer, 2004
- Aurora kinases in spindle assembly and chromosome segregationExperimental Cell Research, 2004
- The cellular geography of Aurora kinasesNature Reviews Molecular Cell Biology, 2003
- The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpointThe Journal of cell biology, 2003
- Functional Significance of the Specific Sites Phosphorylated in Desmin at Cleavage Furrow: Aurora-B May Phosphorylate and Regulate Type III Intermediate Filaments during Cytokinesis Coordinatedly with Rho-kinaseMolecular Biology of the Cell, 2003