EFFECT OF PYRIDOXINE ON PLASMA LEVELS OF HGH, PRL, AND TSH IN NORMAL WOMEN

Abstract
The effect of chronic pyridoxine (vitamin B6) administration on hGH [human growth hormone], basal and TRH [thyroliberin] stimulated PRL prolactin and TSH [thyrotropin] levels was studied in 7 healthy female volunteers. hGH and TSH basal levels remained unaffected. Basal PRL and TRH stimulated PRL and TSH levels were slightly reduced without statisical significance (P > 0.05). Stimulation of the hypothalamic dopaminergic pathway by pyridoxine is apparently highly variable and unpredictable. Therefore, it seems meaningless to recommend vitamin B6 for the treatment of hyperprolactinemia.