THE EFFECTS OF ORAL AND PARENTERAL ADMINISTRATION OF A NEW SYNTHETIC ESTROGEN, BENZESTROL,1IN THE RAT1
- 1 May 1945
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 36 (5) , 297-304
- https://doi.org/10.1210/endo-36-5-297
Abstract
The synthetic estrogen benzestrol, 2,4-di(p-hydroxyphenyl)-3-ethyl hexane, was compared with natural estrogenic hormone at several dosage levels and by several routes of adm. in normal and castrate, young and adult rats, and in castrate adult [female] rabbits. A study of the physiologic. responses, and wt. and histologic. changes of essential organs, showed that the action of this synthetic compound was identical in all respects with that of natural estrogens, and that no "tox-icity" was observed from long continued overdosage. No evidence of malignant changes in any tissue was observed.This publication has 4 references indexed in Scilit:
- STUDIES ON A NEW SERIES OF SYNTHETIC ESTROGENIC SUBSTANCESEndocrinology, 1943
- STUDIES ON STILBESTROL II. THE EFFECT OF MASSIVE DOSES ON NORMAL IMMATURE FEMALE RATSEndocrinology, 1941
- STUDIES ON STILBESTROL I. SOME EFFECTS OF CONTINUOUS INJECTIONS OF STILBESTROL IN THE ADULT FEMALE RATEndocrinology, 1941
- SUMMARY OF SOME CLINICAL REPORTS ON STILBESTROLJournal of Clinical Endocrinology & Metabolism, 1941