INFLUENCE OF AN OVERSULFATED HEPARINOID UPON HYALURONATE METABOLISM OF THE HUMAN SYNOVIAL CELL INVIVO
- 1 January 1979
- journal article
- research article
- Vol. 6 (5) , 554-561
Abstract
Glycosaminoglycans appear to affect proteoglycan metabolism of fibroblasts, human synovial cells and chondrocytes under in vitro conditions. The influence of an oversulfated heparinoid (Arteparon) on hyaluronate metabolism of the human synovial lining cell was studied by in vivo experiments on human volunteers. A higher production of better polymerized hyaluronic acid was seen after repeated intraarticular injections of the heparinoid into the knees of 2 osteoarthritic patients. After a single injection a statistically significant rise of synovial fluid hyaluronate concentration was seen over 4 days. A higher MW of this molecule was suspected in view of a significant increase of the anomalous viscosity index 2 and 4 days after intraarticular administration.This publication has 8 references indexed in Scilit:
- The presence of chondroitin sulphate in the synovial fluid in rheumatoid arthritisClinica Chimica Acta; International Journal of Clinical Chemistry, 1967
- LYSOSOMAL HYALURONIDASE FROM RAT LIVER .2. PROPERTIES1967
- Mucopolysaccharides in Synovial Fluid. Detection of Chondroitin SulphateAnnals of the Rheumatic Diseases, 1966
- Studies on the mode of action of excess of vitamin A. 6. Lysosomal protease and the degradation of cartilage matrixBiochemical Journal, 1963
- Studies on the mode of action of excess of vitamin A. 3. Release of a bound protease by the action of vitamin ABiochemical Journal, 1961
- RHEOLOGIC STUDIES ON SYNOVIAL FLUIDJournal of Clinical Investigation, 1956
- A MODIFIED COLORIMETRIC METHOD FOR THE ESTIMATION OF N-ACETYLAMINO SUGARSJournal of Biological Chemistry, 1955
- Individual Comparisons by Ranking MethodsBiometrics Bulletin, 1945