DOXORUBICIN-INDUCED SKIN ULCER IN THE PIGLET

  • 1 January 1983
    • journal article
    • research article
    • Vol. 67  (12) , 1075-1078
Abstract
Skin ulceration produced by inadvertently extravasated doxorubicin is characterized by a prolonged course accompanied by severe morbidity, and it has proven to be notoriously difficult to treat. In attempts to identify possible antidotes, 11 different pharmacologic agents [carnitine, coenzyme Q10, deferoxamine mesylate, dimethyl sulfoxide (DMSO), dopamine, DNA type V, human serum albumin, iron dextran, isoproterenol, NaHCD3, .alpha.-tocopherol] were tested using piglets, because their skin is anatomically similar to that of man. Among the agents studied, topical application of DMSO daily for 7 days tended to decrease the maximal diameter and accelerate healing of skin ulcers produced by intradermal doxorubicin. .alpha.-Tocopherol appeared to worsen the ulceration. None of the 11 agents studied prevented the development of ulcerations completely.