Role of Streptococcus pyogenes Two-Component Response Regulators in the Temporal Control of Mga and the Mga-Regulated Virulence Gene emm
Open Access
- 1 June 2004
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (6) , 3668-3673
- https://doi.org/10.1128/iai.72.6.3668-3673.2004
Abstract
We examined the role of Streptococcus pyogenes two-component response regulators (SptR) in expression of Mga and the Mga-regulated gene emm . Both serotype M6 and serotype M1 mutants in 12 of the 13 identified sptR genes exhibited levels of emm transcripts and Mga protein comparable to those of the wild type during exponential and stationary phases of growth. Thus, temporal control of these virulence genes does not require Spt response regulators.This publication has 31 references indexed in Scilit:
- amrA encodes a putative membrane protein necessary for maximal exponential phase expression of the Mga virulence regulon in Streptococcus pyogenesMolecular Microbiology, 2003
- Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen–host interactionsTrends in Microbiology, 2003
- Genome-wide protective response used by group AStreptococcusto evade destruction by human polymorphonuclear leukocytesProceedings of the National Academy of Sciences, 2003
- Virulence control in group AStreptococcusby a two-component gene regulatory system: Global expression profiling andin vivoinfection modelingProceedings of the National Academy of Sciences, 2002
- Genome sequence of a serotype M3 strain of group AStreptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergenceProceedings of the National Academy of Sciences, 2002
- Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaksProceedings of the National Academy of Sciences, 2002
- Two DNA‐binding domains of Mga are required for virulence gene activation in the group A streptococcusMolecular Microbiology, 2002
- Complete genome sequence of an M1 strain of Streptococcus pyogenesProceedings of the National Academy of Sciences, 2001
- Pathogenesis of Group A Streptococcal InfectionsClinical Microbiology Reviews, 2000
- Surface protein‐CAT reporter fusions demonstrate differential gene expression in the wr regulon of Streptococcus pyogenesMolecular Microbiology, 1992