PERIPHERAL-BLOOD GRANULOCYTE MACROPHAGE PROGENITORS IN PATIENTS WITH THE MYELODYSPLASTIC SYNDROMES

  • 1 December 1986
    • journal article
    • research article
    • Vol. 14  (11) , 1063-1068
Abstract
Peripheral blood (PB) granulocyte-macrophage progenitor (CFU-GM) growth was measured in 47 normal subjects and, together with bone marrow CFU-GM and blast cell numbers, in 45 newly diagnosed patient with myelodyplastic syndromes (MDS). Both PB colony and cluster numbers were significantly reduced in MDS patients. In patients with > 5% marrow blasts there was a negative correlation between blast cell numbers and PB colony growth. Bone marrow and PB colony growth were also well correlated in this group. Poor growth of PB CFU-GM appears to be more closely related to prognosis than does bone marrow progenitor growth.