Separation and Identification of Sulfonamide Drugs via SFC/FT-IR Mobile-Phase Elimination Interface
- 1 December 1997
- journal article
- research article
- Published by SAGE Publications in Applied Spectroscopy
- Vol. 51 (12) , 1791-1795
- https://doi.org/10.1366/0003702971939848
Abstract
Packed-column supercritical fluid chromatography with a mobile-phase gradient of carbon dioxide and methanol has been performed on a mixture of eight sulfonamides. The analytes were detected and identified with Fourier transform infrared spectrometry. A commercial mobile-phase elimination interface (LC-Transform®) was employed. A fixed-integral restrictor afforded the decompression zone between the column and germanium disk where the analytes were deposited. Excellent-quality infrared spectra were obtained for all eight separated analytes.Keywords
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