Prostaglandin D2-induced potentiation of hexobarbitone hypnosis in rats: role of 5-hydroxytryptamine
- 1 December 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 37 (12) , 915-916
- https://doi.org/10.1111/j.2042-7158.1985.tb05002.x
Abstract
Prostaglandin D2 (PGD2) produced a dose-related increase in the duration and incidence of induction of sleep induced by hexobarbitone, in rats. Pretreatment with pharmacological agents known to reduce selectively brain 5-hydroxytryptaminergic activity, significantly inhibited PGD2-induced potentiation of hexobarbitone, indicating that this potentiation is mediated by 5-hydroxytryptamine.This publication has 10 references indexed in Scilit:
- Sedation produced by prostaglandins is not a nonspecific fatty acid effectPsychopharmacology, 1984
- Effect of brain monoamines on the secretion of adrenocorticotrophic hormoneActa Endocrinologica, 1982
- PGD2 effects on rodent behavior and EEG patterns in catsPharmacology Biochemistry and Behavior, 1980
- The Role of Prostaglandins in the Central Nervous SystemAnnual Review of Physiology, 1979
- Effects of biogenic amines and psychotropic drugs on endogenous prostaglandin biosynthesis in the rat brain homogenatesBiochemical Pharmacology, 1978
- Prostaglandins: effect of prostaglandin E1 on brain, stomach and intestinal serotonin in ratBiochemical Pharmacology, 1978
- Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brainProstaglandins, 1977
- Role of 5-hydroxytryptamine in prostaglandin E1-induced potentiation of hexobarbitone hypnosis in albino ratsCellular and Molecular Life Sciences, 1976
- Effect of prostaglandin E2 on central and peripheral catecholamine neuronsEuropean Journal of Pharmacology, 1973
- TEMPERATURE RESPONSES TO MONOAMINES AND AN INHIBITOR OF MAO INJECTED INTO THE CEREBRAL VENTRICLES OF RATSBritish Journal of Pharmacology and Chemotherapy, 1967