INHIBITION OF DEVELOPMENT OF DCA HYPERTENSION BY A NEW SYNTHETIC STEROID

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Abstract
U-0160 (3,21 diacetoxy-5, 7, 9-pregnatrien-20-one maleic anhydride adduct) was effective in preventing the hypertension produced by DCA in the unilaterally nephrectomized, Na-sensitized rat. This property is not shared by U-0176 (U-0160 less maleic anhydride) or by maleic anhydride itself. U-0160 also largely prevents the cardiac hypertrophy accompanying DCA hypertension, but augments the increase in renal mass. It is considered improbable that the action of the compound is through release of 11-oxygenated hormones from the adrenal cortex, as there is no evidence of adrenal hypertrophy or thymic involution produced by the compound.