Comparative Excretions of Strontium Isotopes in Man

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Abstract
Results obtained in metabolic studies of stable Sr and of 90Sr, which were naturally contained in the diet and the excretions and retention of 85Sr following oral or i.v. administration of tracer doses of 85Sr, were compared in groups of adult males who were studied under strictly controlled dietary conditions. This comparison has shown good agreement between results obtained with stable Sr, 90Sr and 85Sr. Net absorption of stable Sr, of 90Sr and of 85Sr averaged 12, 16 and 20%, respectively. Urinary excretions expressed as percent of intake averaged 17% and 13% for stable Sr and for 90Sr, respectively, and was lower following acute administration of 85Sr. There was a good correlation between urinary excretion of Ca and of each of the 3 Sr isotopes. Very low levels of urinary Ca were associated with very low levels of urinary 90Sr, 85Sr and of stable Sr and vice versa; high excretions of Ca was associated with relatively high excretions of these isotopes. Fecal excretions of the 3 isotopes were rather high and were similar for stable Sr, 90Sr and 85Sr, the average values ranging from 81-88% in the 3 studies.