Strontium-90 Metabolism during Low Strontium-90 Intake in Man

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Abstract
Metabolic balances of Sr9O and calcium were determined in 10 young healthy volunteers under controlled dietary conditions during a low calcium-low Sr90 intake. No radioisotope was administered during the study. The average dietary Sr90 intake was 3.1 [mu][mu]c/day. The major portion of ingested Sr90 passed through the intestine, and the fecal Sr90 excretion was 85% of the Sr90 intake. The net absorption of Sr90 was lower than that of calcium; the average Ca/average Sr90 net absorption ratio was 1.7. The urinary Sr90 excretion was 13% of the ingested Sr90; the average Sr90 balance was 0.1 [plus or minus] 0.3 [mu][mu]c/day. The contribution of the previous Sr90 intake to the urinary and endogenous fecal Sr90 excretion was determined, and the true Sr90 absorption was calculated to be 21% of the Sr9O intake. No major differences were noted in the % absorption and excretion of Sr90 for subjects receiving a low calcium diet (without milk) having a Sr9O/Ca ratio of 19 [mu][mu]c/gm Ca and subjects previously studied on the same diets to which milk was added, having a Sr90/Ca ratio of 11 [mu][mu]c/gm Ca. However, the % absorption and excretion of calcium differed on the 2 dietary intake levels.

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