Effects of Synthetic Atrial Natriuretic Peptides on Sodium-Potassium Transport in Human Erythrocytes

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Abstract
The effects of synthetic human and rat atrial peptides on Na and K ion transport has been investigated in intact human erythrocytes. The effects of these peptides have been tested on the active, Na pump-dependent (ouabain-sensitive) and on the Na-K cotransport system (bumetanide-sensitive) with 86Rb used as a tracer. Human (.alpha.-ANP [atrial natriuretic peptide], 28 amino acids) or rat (atriopeptin II) atrial peptides, over a wide range of concentrations, did not influence the uptake of 86Rb in either the ouabain-sensitive or the bumetanide-sensitive transport system. The natriuretic effect of the atrial peptides may not be mediated through inhibition of the Na pump or the loop-diuretic-sensitive Na-K cotransport.

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