HISTOPATHOLOGY OF THE LENS CAPSULE IN FIBRILLOPATHIA EPITHELIOCAPSULARIS (FEC) OR SO‐CALLED SENILE EXFOLIATION OR PSEUDOEXFOLIATION

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Abstract
Lenses (20) from human cataractous eyes were subjected to enzymatic breakdown by collagenase and .alpha.-chymotrypsin to remove part of the lens capsule and the zonular apparatus. Of the lenses, 12 had clinical fibrillopathia epitheliocapsularis (FEC syndrome). In addition 4 FEC lenses and 4 ordinary cataractous lenses served as controls. A characteristic fibrillar substance was found in the FEC lenses located to circular epithelium near areas varying in size from 10-150 .mu.m. The circular areas were found in zona germinativa in front of the bow region and corresponded to the discoid plaques of the deep layer. The ultrastructure of the finely fibrillar material of the deep layer were indistinguishable from that of the surface material of the peripheral band and the central disc. A connection between the discoid plaques of deep layer and the peripheral granular band were demonstrated in the form of radial cobble-stone sectors seen in partially digested FEC capsules. An increased amount of age dependent spindleshaped formed bodies were also found in FEC lenses. The evidence presented points towards a lenticular origin of the Busacca-bushes in the peripheral ganular band of the lens capsule.

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