Protective effect of nifedipine in the hypoxic perfused cat liver

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Abstract
The effects of the calcium antagonist nifedipine on isolated perfused cat livers were studied during 150 min of normoxic or hypoxic perfusion with Krebs-Henseleit solution. Hypoxic livers perfused with the nifedipine vehicle exhibited significantly higher increases in perfusion pressure, perfusate lactate dehydrogenase and cathepsin D activities, as well as amino-nitrogen concentrations compared to the control normoxic group. In contrast, the nifedipine+hypoxia group showed no significant difference in any of these variables from the control livers. Nifedipine (0.3 μg/ml) protected the liver during hypoxia and that this protection may have stemmed from its inhibition of Ca++ influx which has been linked to irreversible cell death.