Sequence of enzyme synthesis and gene replication during the cell cycle of Bacillus subtilis.

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Abstract
The syntheses of 5 enzymes during the cell cycle of B. subtilis was investigated using synchronous cultures. The autogenous syntheses of 4 and the change in potential to synthesize the fifth were rapid during only a portion of the cell cycle. The times of rapid synthesis could be arranged in an average linear order. This order was the same as that of the corresponding genetic markers for the 4 enzymes for which negative mutants were available. Although the average sequence of autogenous enzyme syntheses was in accordance with the genetic map, some variation was apparent, occasional reversals in order of synthesis of relatively closely linked enzymes in particular cycles. Relative sucrase-transforming activity changed periodically during the cell cycle, and at approximately the same time as the potential for sucrase synthesis.

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