Circumventricular Organs: Gateways to the Brain Axonal Projections From The Organum Vasculosum Lamina Terminalis To The Supraoptic Nucleus: Functional Analysis And Presynaptic Modulation
- 21 July 2001
- journal article
- review article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 28 (7) , 570-574
- https://doi.org/10.1046/j.1440-1681.2001.03488.x
Abstract
SUMMARY: 1. The rat organum vasculosum lamina terminalis (OVLT) contains GABA‐ and glutamate‐releasing neurons that project directly to magnocellular neurosecretory cells (MNC) in the supraoptic nucleus.2. Changes in osmolality over the OVLT in hypothalamic explants cause proportional changes in firing in MNC through corresponding changes in the frequency of spontaneous glutamatergic excitatory post‐synaptic potentials without affecting GABAergic inhibitory post‐synaptic potentials.3. Exogenously applied atrial natriuretic peptide inhibits the osmotic control of MNC by causing a decrease in the amount of glutamate released provoked by action potentials originating from OVLT neurons.Keywords
This publication has 31 references indexed in Scilit:
- OSMORECEPTORS IN THE CENTRAL NERVOUS SYSTEMAnnual Review of Physiology, 1997
- Osmoreceptors, Osmoreception, and OsmoregulationFrontiers in Neuroendocrinology, 1994
- The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor familyPublished by Elsevier ,1989
- A membrane form of guanylate cyclase is an atrial natriuretic peptide receptorNature, 1989
- Role of Anterior Peri‐Third Ventricular Structures in the Regulation of Supraoptic Neuronal Activity and Neurohypophysical Hormone Secretion in the RatJournal of Neuroendocrinology, 1989
- Osmoreceptor mechanism for oxytocin release in the rat.The Japanese Journal of Physiology, 1988
- Hypothalamic action of atrial natriuretic factor to inhibit vasopressin secretionPeptides, 1987
- Atrial natriuretic factor inhibits the stimulated in-vivo and in-vitro release of vasopressin and oxytocin in the ratJournal of Endocrinology, 1986
- Horseradish peroxidase study in rat of the neural connections of the organum vasculosum of the lamina terminalisNeuroscience Letters, 1981