A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family
- 1 April 1986
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 320 (6061) , 415-421
- https://doi.org/10.1038/320415a0
Abstract
A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5′ ▵ gag-kit- ▵ pol- ▵ env 3′ and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus.Keywords
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