INTERNATIONAL COLLABORATIVE STUDY OF N.I.B.S.C. RESEARCH STANDARD FOR HUMAN PARATHYROID HORMONE FOR IMMUNOASSAY

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Abstract
The use of a Research Standard for human parathyroid hormone (PTH) in a collaborative study by 17 laboratories in ten countries is described. Results of this study showed that the Research Standard was not distinguishable by immunoreactive criteria from the other preparations and laboratory working standards of human PTH included in the study. It was, however, shown to be distinguishable from the International Reference Preparation for Parathyroid Hormone, Bovine, for Immunoassay by immunoreactive criteria and by heterogeneity of estimates in terms of bovine PTH. The Research Standard had appropriate biological activities in three different in-vitro bioassay systems and appeared to be stable under conditions of accelerated degradation. This material in ampoules coded 75/549 is now available internationally as N.I.B.S.C. Research Standard for human PTH for immunoassay.

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